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KMID : 0882420060700050581
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Korean Journal of Medicine
2006 Volume.70 No. 5 p.581 ~ p.585
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A case of the primary malignant melanoma arising from uterine endometrium
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엄지은/Uhm JE
임태규/조수진/김승태/배덕수/송상용/박준오/Lim TK/Cho SJ/Kim ST/Bae DS/Song SY/Park JO
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Abstract
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Malignant melanoma arising in the uterine endometrium is extremely rare. Only 12 cases of malignant melanoma of the uterine endometrium have been previously reported to date. All of them were metastatic cases. The most common presenting symptom was abnormal uterine bleeding. We report a case of primary malignant melanoma arising from the uterine endometrium. A 63-year-old multigravid woman presented with uterine bleeding. The pathologic review of an endometrial curettage specimen suggested an undifferentiated malignant tumor. A total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection were performed. Final pathologic examination revealed malignant melanoma. Immunohistochemical studies demonstrated reactivity of tumor cells for HMB-45 and S-100 protein. She had no previous history of malignancy. Whole body PET scan was performed in an effort to find the primary site of malignant melanoma and showed no demonstrable abnormal FDG uptake suggesting malignancy elsewhere. This case is the first report of primary malignant melanoma involving uterine endometrium in Korea.
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KEYWORD
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